Which of the following is most reactive towar | vedclass

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Question

(B) The reactivity of carboxylic acid derivatives towards nucleophilic acyl substitution follows the order: $Acyl \ halide > Acid \ anhydride > Ester

Vedclass · Accepted Answer

$CH_3-C(=O)-Cl$

Vedclass · Answer

(B) The reactivity of carboxylic acid derivatives towards nucleophilic acyl substitution follows the order: $Acyl \ halide > Acid \ anhydride > Ester > Amide$. Among the given options,$CH_3-C(=O)-Cl$ (Acetyl chloride) is the most reactive because $Cl^-$ is a weak base and an excellent leaving group,and the strong $-I$ effect of chlorine increases the electrophilicity of the carbonyl carbon.

Which of the following is most reactive towards nucleophilic attack?

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